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Title	Specific adherence of Escherichia coli (strain RDEC-1) to membranous (M) cells of the Peyer's patch in Escherichia coli diarrhea in the rabbit
Author	Inman, Lindsey R. Cantey, J. Robert
Contributor(s)	Journal of Clinical Investigation (Publisher)
Date	1983-01
Affiliation/College	College of Graduate Studies College of Medicine
Department	Pathology and Laboratory Medicine Medicine
Subject.MeSH	Rabbits Escherichia coli Intraepithelial Lymphocytes Peyer's Patches Diarrhea Ileum Epithelium Epithelial Cells Vaccines Microscopy, Electron
Collection	MUSC Faculty Journal Articles
Contributing Institution	Waring Historical Library (MUSC)
Rights	Copyright © 1983 The American Society for Clinical Investigation, Inc. For more information contact the Waring Historical Library, Charleston, SC 29425.
Language	English
Type	Text
Format	application/pdf
Media Type	Articles
Resource Identifier	fja_1983_0003
Note	Article source publication: Inman, L. R. & Cantey, J. R. (1983). Specific adherence of Escherichia coli (strain RDEC-1) to membranous (M) cells of the Peyer's patch in Escherichia coli diarrhea in the rabbit. The Journal of Clinical Investigation, 71(1), 1-8: https://doi.org/10.1172/JCI110737
Abstract	The RDEC-1 strain Escherichia coli is an enteroadherent bacterium that produces diarrhea in the rabbit. A histopathologically similar disease has been described in humans. The RDEC-1 bacterium adheres to the epithelium of lymphoid follicles in rabbit ileal Peyer's patches by 4 h postinoculation, 3-4 d before its adherence to absorptive epithelium. The purpose of this study was to determine whether the RDEC-1 bacterium adheres to a specific cell type in the lymphoid follicle epithelium. RDEC-1 bacteria were given in a dose of 2 X 10(6) by the orogastric route to postweanling rabbits. The distal ileal Peyer's patch, taken from 5 control rabbits and 43 rabbits at intervals in the first 24 h postinoculation, was examined by routine and high-voltage electron microscopy. The RDEC-1 bacterium adhered specifically to M (membranous) rather than absorptive epithelial cells of the lymphoid follicle epithelium. Further understanding of how the bacterium attaches to M cells, which transport antigens to intraepithelial lymphocytes, could be useful in designing vaccines to protect mucosal surfaces.

Specific adherence of Escherichia coli (strain RDEC-1) to membranous (M) cells of the Peyer's patch in Escherichia coli diarrhea in the rabbit

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