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Title	Immunoglobulins and Fc gamma receptor genes influence the control of HIV replication and the progression of HIV infection
Author	Deepe, Ray
Date	2011
Affiliation/College	College of Graduate Studies
Department	Microbiology and Immunology
Extent	iv, 61 leaves : ill.; 29 cm
Subject.MeSH	Academic Dissertations Academic Dissertations--South Carolina Immunoglobulins Receptors, IgC HIV
Collection	MUSC Theses and Dissertations
Contributing Institution	Waring Historical Library (MUSC)
Rights	Copyright is held by the author.
Language	English
Type	Text
Format	application/pdf
Media Type	Manuscripts
Resource Identifier	mtd2011_deepe_r
Abstract	HIV is an infection affecting approximately 33 million people worldwide especially in Sub-Saharan Africa and Southeastern Asia. HIV infection is marked by the loss of CD4+ T -cells and is the causative agent of AIDS. Host genetic factors have been shown to influence the progression and outcome of HIV infection, but the genes identified thus far account for approximately 15% of the variance observed in viral load and progression, suggesting involvement of additional genes in HIV pathogenesis. FcyRlla and FcyRIIIa genotypes have been shown to be influential in the transmission, control, and progression of HIV. These receptors contain pol ymorphisms that influence binding affinity for their ligand, the Fc region of IgG. The Fc region is also highly polymorphic and could potentially contribute to the differences seen in control and progression. Yet, these polymorphisms, known as GM allotypes, have not been investigated. Determinants expressed on Fc (GM) and FcyR are probably some of the most likely ligand-receptor candidate pairs for gene-gene interactions in the human genome. Thus, the aim of this investigation was to determine whether particular GM and FcyRIla, genotypes were individually or epistatically associated with the host control of HIV replication and progression of HIV to a low CD4+ T-cell count. This study suggests that while no GM allotype is influential by itself, particular combinations of FcyR-GM are influential in the control of HIV replication as well as the progression of HIV to a low CD4+ T-cell count.

Immunoglobulins and Fc gamma receptor genes influence the control of HIV replication and the progression of HIV infection

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