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Title	A likelihood-based approach to early stopping in single arm phase II clinical trials
Author	Garrett-Mayer, Elizabeth; Wahlquist, Amy E.
Date	2011
Subject.MeSH	Clinical Trials as Topic Clinical Trials as Topic -- methods Clinical Trial Clinical Trial, Phase II Clinical Trials, Phase II as Topic
Description	Phase II studies in oncology have evolved over the previous several decades. Currently, the number of drugs in phase II development has increased, and patient eligibility has narrowed due to targeted agents, competing trials and curative therapies in the first-line setting. As a result of these changes, more attention needs to be focused toward conducting more efficient phase II trials. Given the increased difficulty in accruing patients to phase II studies and the ethical concern of treating patients with agents that are ineffective, there is significant motivation to stop a single arm trial early when the investigational agent shows evidence of a low response rate.
Collection	MUSC Department of Public Health Sciences Working Papers Working Papers
Contributing Institution	Waring Historical Library (MUSC)
Date Digital	2011
Rights	Copyright is held by the author.
Language	English
Type	Text
Format	application/pdf
Media Type	Manuscripts
Resource Identifier	11-001
Bibliographic Citation	Elizabeth Garrett-Mayer, Amy E. Wahlquist. A likelihood-based approach to early stopping in single arm phase II clinical trials, MUSC Division of Biostatistics and Epidemiology Working Papers, 2011. http://medica.library.musc.edu/p/bew/99

A likelihood-based approach to early stopping in single arm phase II clinical trials

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