A likelihood-based approach to early stopping in single arm phase II clinical trials
Rating
Title
A likelihood-based approach to early stopping in single arm phase II clinical trials
Author
Garrett-Mayer , Elizabeth ; Wahlquist , Amy E .
Date
2011
Subject.MeSH
Clinical Trials as Topic Clinical Trials as Topic -- methods Clinical Trial Clinical Trial, Phase II Clinical Trials, Phase II as Topic
Description
Phase II studies in oncology have evolved over the previous several decades . Currently , the number of drugs in phase II development has increased , and patient eligibility has narrowed due to targeted agents , competing trials and curative therapies in the first-line setting . As a result of these changes , more attention needs to be focused toward conducting more efficient phase II trials . Given the increased difficulty in accruing patients to phase II studies and the ethical concern of treating patients with agents that are ineffective , there is significant motivation to stop a single arm trial early when the investigational agent shows evidence of a low response rate .
Collection
MUSC Department of Public Health Sciences Working Papers Working Papers
Contributing Institution
Waring Historical Library (MUSC)
Date Digital
2011
Rights
Copyright is held by the author.
Language
English
Type
Text
Format
application/pdf
Media Type
Manuscripts
Resource Identifier
11-001
Bibliographic Citation
Elizabeth Garrett-Mayer, Amy E. Wahlquist. A likelihood-based approach to early stopping in single arm phase II clinical trials, MUSC Division of Biostatistics and Epidemiology Working Papers, 2011. http://medica.library.musc.edu/p/bew/99
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