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Title	Contractile force
Creator Name	Walton, Robert P. (Robert Petrie), 1905-1971
Date	1948
Duration	00:05:00
Extent	1 videodisc (DVD) (5 min.): sd., col.; 4 3/4 in.
Source	VM 100 DVD 1948
Subject.LCSH	Halushka, Perry V.;Medical College of the State of South Carolina
Subject.MeSH	Heart Rate Myocardial Contraction Epinephrine Cardiovascular Physiological Phenomena Digitalis Heart--drug effects
Description	The film depicts an "open chest preparation." The chest is opened at the midline of the sternum. The subject is placed on a respirator and artificially ventilated. The lungs can be seen in the background expanding and contracting. The two rods placed in the heart muscle measure both the force of contraction and the heart rate. When the operator pulls up on the string attached to the rod, he is measuring indirectly the force of contraction. Notice, he is measuring the distance that he moves the string up the rod and records the distance moved. This in turn is translated into a force of contraction. Those 2 measurements are depicted on the graph. There are 3 drugs being tested; epinephrine, digitalis and EA-83. The 3 drugs were injected intravenously in a vein that is not seen in the film. All three drugs increased the force of contraction of the heart. Epinephrine and EA-83 also increased the heart rate. The graph of EA-83 shows the time course of the increase in contractile force that it produced. This reasearch was conducted by Dr. Robert Walton, Chair of the MCSSC Department of Pharmacology. Description provided by Dr. Perry Halushka, Dean of the MUSC College of Graduate Studies and former student of Dr. Robert Walton.
Digital Collection	Waring Historical Library Video Collection
Website	http://digital.library.musc.edu/cdm/landingpage/collection/whlvideo
Contributing Institution	Waring historical Library (MUSC)
Date Digital	2015
Rights	Copyright is held the Waring Historical Library, MUSC. For more information, please contact the Waring Historical Library.
Language	English
SC County	Charleston County (S.C.)
Type	Moving Image
Format	video/mp4
Media Type	Film
Resource Identifier	whlvideo_001
Note	Preserved with the assistance of the National Film Preservation Foundation Basic Preservation Grant. In addition to the DVD and DBC copies housed at the Waring Historical Library, (1) a 16mm color silent answer print, (2) a 16mm A wind preservation color internegative, and (3) a 16mm cut Kodachrome reversal original are being housed at the University of South Carolina Moving Image Research Collection cold storage vault in Columbia, South Carolina. Also available as 1/2 in. videocassette (DBC).

Contractile force

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